The 2021 Topps Series 2 release picks up where the Series 1 release leaves off. It features a 330 card base set, continuing on beginning with 331. The same parallels are present, as well as many of the same insert sets contained in the first release. We see the continuation of the 1986 design inserts, as well.

A box comes with ten packs of 46 cards, and advertises 1 autograph and 2 relic cards. Also included in each box are two “silver packs” containing chrome versions of a few of the insert sets. A few years ago, these silver packs were available as a wrapper main-in rebate, but are now included inside of the box.

This box contained:

413 Base (100% of 330 card set)
1 Base SP Anthony Rendon
2 Base Gold Parallels
5 Base Gold Foil Parallels
5 Base Rainbow Foil Parallels
1 Base Red Ice Parallel
5 70 Years of Topps Baseball
5 1986 Topps All-Stars
5 1986 Topps
1 DH Debuts
1 Home Run Challenge
1 Platinum Players Die-Cuts
1 Platinum Players Die-Cuts Blue
1 Significant Statistics
1 Significant Statistics Blue Parallel
2 Zero to Sixty
2 70 Years of Topps Baseball Chrome
8 1986 Topps Chrome
1 1986 Topps All-Star Relics Miguel Cabrera
1 Rookie Card Patches Ryan Mountcastle
1 70 Years of Baseball Autographs Jahmai Jones